On a sunny day, in the heart of America, the loveliest of suburbs, housewife Mary Alice Young (Brenda Strong) killed herself. Now she takes us into the lives of her friends, family and neighbors... Her circle of girlfriends on Wisteria Lane includes Bree Hodge (Marcia Cross), Martha Stewart on steroids, who recently battled the demons of widowhood, alcoholism and vengeful children...she remarried and now tries to keep her image of perfection even as everything crumbles around her; Lynette Scavo (Felicity Huffman), who struggles with balancing the complications of work, family issues and now cancer; Susan Mayer (Teri Hatcher), until recently a divorcee and single mom, finally got her happy ending when she tied the knot with the hot plumber next door but is now faced with the challenges of a blended family; newlywed Gabrielle Marquez, the ex-model who seems to be unlucky in love; and serial divorcee Edie Britt (Nicollette Sheridan), the free spirited real estate maven whose love life has everyone buzzing.