Four months after the events of the showdown between Sylar and Peter, new Heroes emerge. These include Blackie, an Irish mobster who is 1,000 years old. Hiro remains in the past, but what will come of this? Someone dies and someone isn't dead. Claire has a boyfriend. New heroes are introduced.

As the second volume of “Heroes” begins, the fates of Peter (Milo Ventimiglia), Nathan (Adrian Pasdar) and Matt (Greg Grunberg) are revealed, following the horrible showdown with Sylar (Zachary Quinto) and Peter’s uncontrolled nuclear detonation miles above New York City. As everyone attempts to move on, a new sinister force begins stalking and murdering Heroes. With the family hiding in Southern California, H.R.G. (Jack Coleman) and Claire (Hayden Panettiere) attempt to live as inconspicuously as possible, which proves to be easier said than done. Meanwhile, after landing in feudal Japan, Hiro (Masi Oka) meets his hero Takezo Kensei (David Anders). Twins Maya (Dania Ramirez) and Alejandro Herrera (Shalim Ortiz) hope to make the crossing into the U.S. from Mexico, in hopes of finding help with their deadly abilities.

We meet someone from Louisiana. She has a power. Kensei's power will be revealed.

With one person dead, Matt (Greg Grunberg) enlists some unlikely help as the attacks continue on people with abilities. Claire’s (Hayden Panettiere) efforts to hide her healing abilities at her new California high school are jeopardized by a fellow student with a secret of his own. Niki (Ali Larter) and Micah (Noah Gray-Cabey) leave Las Vegas in an attempt to start over. As part of his new job, Dr. Suresh (Sendhil Ramamurthy) must track down The Haitian (guest star Jimmy Jean-Louis). While crossing into Mexico, Maya (Dania Ramirez) and Alejandro’s (Shalim Ortiz) abilities prove to be a threat to those around them. Meanwhile, disappointed by his hero Kensei (David Anders), Hiro (Masi Oka) resolves to rectify any damage his presence in feudal Japan has done to history. And another lost Hero falls in with a gang of Irish gangsters with clues to his past.

Upon his return to New York, Suresh (Sendhil Ramamurthy) is unnerved to find an undiscovered Issac Mendez painting that foretells death of someone close to him. Both Claire (Hayden Panettiere) and H.R.G. (Jack Coleman) pursue their own secret personal agendas. Determined to make it to the U.S., Maya (Dania Ramirez) uses her deadly abilities to free Alejandro (Shalim Ortiz) from a Mexican jail. Ando (James Kyson Lee) returns to his job in Japan and makes a happy discovery. Meanwhile, in Japan’s past, just when Hiro (Masi Oka) had written off Kensei (David Anders), his childhood hero surprises him. Niki (Ali Larter) and a lost Hero individually strike shady bargains to reach their goals. Two familiar people with abilities make an unexpected return.

Hiro and Ando reunite.